Grape seed extract7/8/2023 In animal studies, GSE has been shown to enhance the effect of different types of chemotherapy ( 42, 43, 44). The antioxidant activity of GSE has shown potential to inhibit human breast, lung, gastric, oral squamous cell, liver, prostate, and pancreatic cell lines in lab settings ( 38, 39, 40, 41). The causes of cancer are complex, though DNA damage is a central characteristic.Ī high intake of antioxidants, such as flavonoids and proanthocyanidins, are associated with a reduced risk of various cancers ( 37). Summary GSE may inhibit a variety of microbes and offer protection against antibiotic-resistant bacterial strains, foodborne bacterial illnesses, and fungal infections like candida. Unfortunately, human studies on GSE’s ability to help treat infections are still lacking. ![]() The infection was inhibited after 5 days and gone after 8 ( 36). ![]() In one study, mice with vaginal candidiasis were given an intravaginal GSE solution every 2 days for 8 days. GSE is widely used in traditional medicine as a remedy for candida. In lab studies, GSE has been found to inhibit 43 strains of antibiotic-resistant Staphylococcus aureus bacteria ( 35).Ĭandida is a common yeast-like fungus that can sometimes result in candida overgrowth, or thrush. coli, both of which are often responsible for severe food poisoning and abdominal upset ( 33, 34). Studies have shown that GSE inhibits the growth of common foodborne bacteria, including Campylobacter and E. GSE displays promising antibacterial and antifungal properties. Summary GSE shows potential to inhibit many of the degenerative characteristics of brain and cognitive decline. However, human studies on the use of GSE in adults with preexisting memory or cognitive deficits are lacking. One 12-week study in 111 healthy older adults found that taking 150 mg of GSE daily improved attention, language, and both immediate and delayed memory ( 28). One of the components of GSE is gallic acid, which animal and lab studies have shown can inhibit the formation of fibrils by beta-amyloid peptides ( 23).Ĭlusters of beta-amyloid proteins in the brain are characteristic of Alzheimer’s disease ( 23).Īnimal studies have found that GSE may prevent memory loss, improve cognitive status and brain antioxidant levels, and reduce brain lesions and amyloid clusters ( 24, 25, 26, 27). However, human-based research is lacking.įlavonoids’ combination of antioxidant and anti-inflammatory properties are thought to delay or reduce the onset of neurodegenerative diseases like Alzheimer’s disease ( 22). Summary Animal studies show promising results regarding GSE’s ability to help treat arthritic conditions and promote collagen health. GSE also significantly reduced pain, bony spurs, and joint damage in osteoarthritic mice, improving collagen levels and reducing cartilage loss ( 21).ĭespite promising results from animal research, human studies are lacking. Rheumatoid arthritis is an autoimmune condition that results in severe inflammation and the destruction of bone and joints.Īnimal studies have shown that GSE may suppress bone destruction in inflammatory autoimmune arthritis ( 18, 19, 20). In fact, animal studies have found that adding GSE to either a low calcium, standard, or high calcium diet can increase bone density, mineral content, and bone strength ( 16, 17). Increasing flavonoid consumption may improve collagen synthesis and bone formation.Īs a rich source of flavonoids, GSE may thus help increase your bone density and strength. May improve collagen levels and bone strength Summary GSE may help reduce your risk of heart disease by inhibiting the oxidation of LDL (bad) cholesterol and reducing oxidation to heart tissue during times of stress.Ĥ. Therefore, GSE likely protected against further heart damage ( 15). However, a similar study was unable to replicate these results ( 5, 12).Īdditionally, a study in 87 people undergoing heart surgery found that taking 400 mg of GSE the day before surgery significantly reduced oxidative stress. In another study, 61 healthy adults saw a 13.9% reduction in oxidized LDL after taking 400 mg of GSE. ![]() ![]() When 8 healthy people ate a high fat meal, taking 300 mg of GSE inhibited the oxidation of fats in the blood, compared with a 150% increase seen in those who did not take GSE ( 14). Some research in humans shows similar results ( 12, 13). GSE supplements have been found to reduce LDL oxidation triggered by high fat diets in several animal studies ( 9, 10, 11). The oxidation of LDL cholesterol significantly increases this risk and plays a central role in atherosclerosis, or the buildup of fatty plaque in your arteries ( 8). An elevated blood level of LDL (bad) cholesterol is a known risk factor for heart disease.
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